SG Talk

No more monoclonal antibody treatments for Covid are available in the U.S.: The Food and Drug Administration on Wednesday rescinded its authorization of bebtelovimab, a drug previously given to patients who faced a high risk of severe disease.

Over the last two years, the FDA authorized six monoclonal antibody treatments for Covid, but omicron’s many subvariants rendered the drugs less effective so the FDA gradually revoked each of those authorizations. Bebtelovimab, made by Eli Lilly, was the last one standing.

https://www.nbcnews.com/health/health-ne...-rcna59797

Overall, the study's results indicated that the four newly emergent SARS-CoV-2 Omicron subvariants BQ.1, BQ.1.1, XBB, and XBB.1 were partially or completely resistant to neutralization by sera from individuals with mono- and bi-valent vaccines and previous SARS-CoV-2 infections. Furthermore, the four new subvariants were resistant to all the monoclonal antibody therapies currently in clinical use.

The findings highlight concerns about the ineffectiveness of current vaccines and monoclonal antibody treatments against rapidly emerging SARS-CoV-2 variants with increased immune evasion abilities.

https://www.news-medical.net/news/202211...iants.aspx