[theold]

Collectively, we provide a comprehensive characterization of the immune responses induced by inactivated COVID-19 vaccines in real-world settings. While a single vaccination was insufficient to induce robust immune responses, both humoral and cellular SARS-CoV-2-specific immunity could be elicited in the majority of individuals who received two inactivated COVID-19 vaccine doses.

We show that the magnitude of SARS-CoV-2-specific CD4+ T cell responses was already significantly increased after a single dose vaccination and further increased after the second administration. 

The SARS-CoV-2-specific CD4+ T cell responses were detectable in over 95% of participants after two doses and S- and N-specific CD4+ T cell responses were significantly stronger than M-specific CD4+ T cell responses. 

Similarly, it has been reported that in COVID-19 patients the CD4 T cell responses to S are the most abundantly detected responses, followed by the responses to N and M (24–26).

Because the whole virus is presented to the immune system, immune responses are likely to target not only the spike protein of SARS-CoV-2 but also the matrix, envelope and nucleoprotein

https://www.frontiersin.org/articles/10....02858/full

[webinarian]

Parents should be allowed to choose vaccine for their kids, Pfizer or Sinovac. 

MOH only mentioned there could be side effects like muscle pain or fever but didn't disclose risk of myocarditis. 

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