![](https://i.imgur.com/CLvY2jA.png")
04-06-2023, 12:36 PM
The immune system “learns” to tolerate a foreign, although innocuous, antigen. However, a very different situation occurs when a virus invades our body.
In this scenario, vaccine-induced tolerance can potentially have several negative, unintended consequences because tolerance to the spike protein could inhibit the immune system from detecting and attacking the pathogen (Figure 4); thus, potentially exacerbating SARS-CoV2 pathology in susceptible individuals who suffer re-infection of COVID-19 in the setting of vaccine-induced immune suppression.
For example, it was demonstrated that patients with severe COVID-19 who passed away had higher IgG4 levels than those who recovered [28].
More precisely, the death rate increased noticeably at 30 days when serum IgG4 concentrations were above 700 mg/dL, and the ratio of IgG4 to IgG1 was above 0.05 [29]. Moreover, IgG4 levels were correlated with IL-6 levels [130], a known determinant of COVID-19-related mortality [130,131,132].
https://www.mdpi.com/2076-393X/11/5/991
In this scenario, vaccine-induced tolerance can potentially have several negative, unintended consequences because tolerance to the spike protein could inhibit the immune system from detecting and attacking the pathogen (Figure 4); thus, potentially exacerbating SARS-CoV2 pathology in susceptible individuals who suffer re-infection of COVID-19 in the setting of vaccine-induced immune suppression.
For example, it was demonstrated that patients with severe COVID-19 who passed away had higher IgG4 levels than those who recovered [28].
More precisely, the death rate increased noticeably at 30 days when serum IgG4 concentrations were above 700 mg/dL, and the ratio of IgG4 to IgG1 was above 0.05 [29]. Moreover, IgG4 levels were correlated with IL-6 levels [130], a known determinant of COVID-19-related mortality [130,131,132].
https://www.mdpi.com/2076-393X/11/5/991
