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10-02-2023, 08:29 AM
Our data demonstrate that XBB.1.5 substantially escapes NAb responses but not T cell responses after bivalent mRNA boosting. NAb titers to XBB.1 and XBB.1.5 were similar, suggesting that the F486P mutation confers greater transmissibility but not increased immune
escape.
By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
The combination of low magnitude and rapidly waning NAb titers to XBB.1.5 will likely reduce the efficacy of the
bivalent mRNA boosters5 , but cross-reactive T cell responses, which were present prior to boosting, may continue to provide protection against severe disease.
https://www.biorxiv.org/content/10.1101/...1.full.pdf
escape.
By month 3, NAb titers to XBB.1 and XBB.1.5 declined essentially to baseline levels prior to boosting, while NAb titers to other variants declined less strikingly.
The combination of low magnitude and rapidly waning NAb titers to XBB.1.5 will likely reduce the efficacy of the
bivalent mRNA boosters5 , but cross-reactive T cell responses, which were present prior to boosting, may continue to provide protection against severe disease.
https://www.biorxiv.org/content/10.1101/...1.full.pdf
