[Manthink]

Broader immune respone is very logical to me. It is like you are teaching a young kid who has never seen a rambutan. You can cut out the rambutan "hairs" (like the protein spikes of the covid virus) and tell him to use them to recognise the fruit , but best teaching method will still be to show him/her the whole fruit.

But inactivated virus vaccine yields a lower antibody response, so one should always wear a mask to reduce the virus intake to allow time for the immune system to warm up to fight the viruses that replicates (exponentially?) within the body.

The rambutan analogy on inactivated virus vaccine is more or less correct - Teaching how to recognise the fruit by not being too specific.

It's like non-mRNA a generalist and mRNA a specialist - each has pros and cons.